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Risk of bladder can...
Risk of bladder cancer by disease severity in relation to metabolic factors and smoking : A prospective pooled cohort study of 800,000 men and women
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- Teleka, Stanley (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci Malmo, Lund, Sweden
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- Häggström, Christel (author)
- Uppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Näringsforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;,Endokrinkirurgi,Umea Univ, Dept Biobank Res, Umea, Sweden;Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden,Umea Univ, Sweden; Uppsala Univ, Sweden
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- Nagel, Gabriele (author)
- University of Ulm,Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany;Vorarlberg Canc Registry, Agcy Prevent & Social Med, Bregenz, Aks, Austria
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- Bjørge, Tone (author)
- University of Bergen,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Canc Registry Norway, Oslo, Norway
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Surg, Malmo, Sweden
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- Ulmer, Hanno (author)
- Medical University of Innsbruck,Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Lund Univ, Inst Translat Med, Div Urol Res, Malmo, Sweden
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- Ghaderi, Sara (author)
- University of Bergen,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway
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- Lang, Alois (author)
- Agency for Preventive and Social Medicine Vorarlberg,Vorarlberg Canc Registry, Agcy Prevent & Social Med, Bregenz, Aks, Austria
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- Jonsson, Håkan (author)
- Umeå universitet,Umeå University,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden
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- Jahnson, Staffan (author)
- Linköpings universitet,Linköping University,Linkoping Univ, Dept Urol, Linkoping, Sweden;Linkoping Univ, IKE, Linkoping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Lund, Sweden
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- Tretli, Steinar (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,Canc Registry Norway, Oslo, Norway
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- Stattin, Pär (author)
- Uppsala universitet,Uppsala University,Urologkirurgi,Uppsala Univ, Sweden
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- Stocks, Tanja (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Register-based epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Lund, Sweden
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(creator_code:org_t)
- 2018-10-16
- 2018
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 143:12, s. 3071-3082
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Abstract
Subject headings
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- Previous studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811,633 participants in six European cohorts, we investigated sex-specific associations between body mass index (BMI), mid-blood pressure (BP, [systolic + diastolic]/2), plasma glucose, triglycerides, total cholesterol and risk of BC overall, non-muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). Among men, we additionally assessed additive interactions between metabolic factors and smoking on BC risk. During follow-up, 2,983 men and 754 women were diagnosed with BC. Among men, triglycerides and BP were positively associated with BC risk overall (hazard ratio [HR] per standard deviation [SD]: 1.17 [95% confidence interval (CI) 1.06–1.27] and 1.09 [1.02–1.17], respectively), and among women, BMI was inversely associated with risk (HR: 0.90 [0.82–0.99]). The associations for BMI and BP differed between men and women (pinteraction ≤ 0.005). Among men, BMI, cholesterol and triglycerides were positively associated with risk for NMIBC (HRs: 1.09 [95% CI 1.01–1.18], 1.14 [1.02–1.25], and 1.30 [1.12–1.48] respectively), and BP was positively associated with MIBC (HR: 1.23 [1.02–1.49]). Among women, glucose was positively associated with MIBC (HR: 1.99 [1.04–3.81]). Apart from cholesterol, HRs for metabolic factors did not significantly differ between MIBC and NMIBC, and there were no interactions between smoking and metabolic factors on BC. Our study supports an involvement of metabolic aberrations in BC risk. Whilst some associations were significant only in certain sub-groups, there were generally no significant differences in associations by smoking or tumor invasiveness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- bladder cancer
- metabolic factors
- muscle-invasive bladder cancer
- non-muscle invasive bladder cancer
- smoking
- bladder cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Teleka, Stanley
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Häggström, Chris ...
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Nagel, Gabriele
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Bjørge, Tone
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Manjer, Jonas
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Ulmer, Hanno
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Liedberg, Fredri ...
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Ghaderi, Sara
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Lang, Alois
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Jonsson, Håkan
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Jahnson, Staffan
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Orho-Melander, M ...
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Tretli, Steinar
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Stattin, Pär
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Stocks, Tanja
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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International Jo ...
- By the university
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Lund University
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Umeå University
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Uppsala University
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Linköping University